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Digoxin absorption decreased independently of P-gp activity in rats with irinotecan-induced gastrointestinal damage
BACKGROUND: Irinotecan (CPT-11) is clinically known to cause severe diarrhea and gastrointestinal damage. Recently, we have reported that CPT-11-induced gastrointestinal damage is associated with the upregulation of intestinal P-glycoprotein (P-gp) expression and decreased absorption of its substrat...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247139/ https://www.ncbi.nlm.nih.gov/pubmed/34193275 http://dx.doi.org/10.1186/s40780-021-00207-w |