PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1

BACKGROUND: The oncogenic PIM kinases and the tumor-suppressive LKB1 kinase have both been implicated in the regulation of cell growth and metabolism, albeit in opposite directions. Here we investigated whether these kinases interact with each other to influence AMPK activation and tumorigenic growt...

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Detalles Bibliográficos
Autores principales: Mung, Kwan Long, Eccleshall, William B., Santio, Niina M., Rivero-Müller, Adolfo, Koskinen, Päivi J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247201/
https://www.ncbi.nlm.nih.gov/pubmed/34193159
http://dx.doi.org/10.1186/s12964-021-00749-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247201/
https://www.ncbi.nlm.nih.gov/pubmed/34193159
http://dx.doi.org/10.1186/s12964-021-00749-4

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