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PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1
BACKGROUND: The oncogenic PIM kinases and the tumor-suppressive LKB1 kinase have both been implicated in the regulation of cell growth and metabolism, albeit in opposite directions. Here we investigated whether these kinases interact with each other to influence AMPK activation and tumorigenic growt...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247201/ https://www.ncbi.nlm.nih.gov/pubmed/34193159 http://dx.doi.org/10.1186/s12964-021-00749-4 |