Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine

AIMS: Carbamazepine can cause hypersensitivity reactions in ~10% of patients. An immunogenic effect can be produced by the electrophilic 10,11‐epoxide metabolite but not by carbamazepine. Hypothetically, certain single nucleotide polymorphisms might increase the formation of immunogenic metabolites,...

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Detalles Bibliográficos
Autores principales: Yip, Vincent L.M., Pertinez, Henry, Meng, Xiaoli, Maggs, James L., Carr, Daniel F., Park, B. Kevin, Marson, Anthony G., Pirmohamed, Munir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247401/
https://www.ncbi.nlm.nih.gov/pubmed/33217013
http://dx.doi.org/10.1111/bcp.14667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247401/
https://www.ncbi.nlm.nih.gov/pubmed/33217013
http://dx.doi.org/10.1111/bcp.14667

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