Endothelial‐protective effects of a G‐protein‐biased sphingosine‐1 phosphate receptor‐1 agonist, SAR247799, in type‐2 diabetes rats and a randomized placebo‐controlled patient trial

AIMS: SAR247799 is a G‐protein‐biased sphingosine‐1 phosphate receptor‐1 (S1P(1)) agonist designed to activate endothelial S1P(1) and provide endothelial‐protective properties, while limiting S1P(1) desensitization and consequent lymphocyte‐count reduction associated with higher doses. The aim was t...

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Detalles Bibliográficos
Autores principales: Bergougnan, Luc, Andersen, Grit, Plum‐Mörschel, Leona, Evaristi, Maria Francesca, Poirier, Bruno, Tardat, Agnes, Ermer, Marcel, Herbrand, Theresa, Arrubla, Jorge, Coester, Hans Veit, Sansone, Roberto, Heiss, Christian, Vitse, Olivier, Hurbin, Fabrice, Boiron, Rania, Benain, Xavier, Radzik, David, Janiak, Philip, Muslin, Anthony J., Hovsepian, Lionel, Kirkesseli, Stephane, Deutsch, Paul, Parkar, Ashfaq A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247405/
https://www.ncbi.nlm.nih.gov/pubmed/33125753
http://dx.doi.org/10.1111/bcp.14632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247405/
https://www.ncbi.nlm.nih.gov/pubmed/33125753
http://dx.doi.org/10.1111/bcp.14632

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