Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease

The strongest genetic risk factor for idiopathic late‐onset Alzheimer's disease (LOAD) is apolipoprotein E (APOE) ɛ4, while the APOE ɛ2 allele is protective. However, there are paradoxical APOE ɛ4 carriers who remain disease‐free and APOE ɛ2 carriers with LOAD. We compared exomes of healthy APO...

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Detalles Bibliográficos
Autores principales: Kim, Young Won, Al‐Ramahi, Ismael, Koire, Amanda, Wilson, Stephen J., Konecki, Daniel M., Mota, Samantha, Soleimani, Shirin, Botas, Juan, Lichtarge, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Theoretical Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247413/
https://www.ncbi.nlm.nih.gov/pubmed/33576571
http://dx.doi.org/10.1002/alz.12240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247413/
https://www.ncbi.nlm.nih.gov/pubmed/33576571
http://dx.doi.org/10.1002/alz.12240

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