Cargando…
Met(166)‐Glu(168) residues in human PrP β2‐α2 loop account for evolutionary resistance to prion infection
AIMS: The amino acid sequence of prion protein (PrP) is a key determinant in the transmissibility of prion diseases. While PrP sequence is highly conserved among mammalian species, minor changes in the PrP amino acid sequence may confer alterations in the transmissibility of prion diseases. Classica...
Autores principales: | Espinosa, Juan Carlos, Marín‐Moreno, Alba, Aguilar‐Calvo, Patricia, Torres, Juan María |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247420/ https://www.ncbi.nlm.nih.gov/pubmed/33253417 http://dx.doi.org/10.1111/nan.12676 |
Ejemplares similares
-
Canine D(163)-PrP polymorphic variant does not provide complete protection against prion infection in small ruminant PrP context
por: Marín-Moreno, Alba, et al.
Publicado: (2021) -
Allelic Interference in Prion Replication Is Modulated by the Convertibility of the Interfering PrP(C) and Other Host-Specific Factors
por: Espinosa, Juan Carlos, et al.
Publicado: (2021) -
The Structure of PrP(Sc) Prions
por: Wille, Holger, et al.
Publicado: (2018) -
Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP
por: Sakudo, Akikazu, et al.
Publicado: (2015) -
Exploration of the Main Sites for the Transformation of Normal Prion Protein (PrP(C)) into Pathogenic Prion Protein (PrP(sc))
por: Liu, Xi-Lin, et al.
Publicado: (2017)