Loss of MUNC18‐1 leads to retrograde transport defects in neurons

Loss of the exocytic Sec1/MUNC18 protein MUNC18‐1 or its target‐SNARE partners SNAP25 and syntaxin‐1 results in rapid, cell‐autonomous and unexplained neurodegeneration, which is independent of their known role in synaptic vesicle exocytosis. cis‐Golgi abnormalities are the earliest cellular phenoty...

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Detalles Bibliográficos
Autores principales: van Berkel, Annemiek A., Santos, Tatiana C., Shaweis, Hesho, van Weering, Jan R. T., Toonen, Ruud F., Verhage, Matthijs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247427/
https://www.ncbi.nlm.nih.gov/pubmed/33259669
http://dx.doi.org/10.1111/jnc.15256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247427/
https://www.ncbi.nlm.nih.gov/pubmed/33259669
http://dx.doi.org/10.1111/jnc.15256

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