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Loss of MUNC18‐1 leads to retrograde transport defects in neurons
Loss of the exocytic Sec1/MUNC18 protein MUNC18‐1 or its target‐SNARE partners SNAP25 and syntaxin‐1 results in rapid, cell‐autonomous and unexplained neurodegeneration, which is independent of their known role in synaptic vesicle exocytosis. cis‐Golgi abnormalities are the earliest cellular phenoty...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247427/ https://www.ncbi.nlm.nih.gov/pubmed/33259669 http://dx.doi.org/10.1111/jnc.15256 |