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Assessing efficacy in important subgroups in confirmatory trials: An example using Bayesian dynamic borrowing

Assessment of efficacy in important subgroups – such as those defined by sex, age, race and region – in confirmatory trials is typically performed using separate analysis of the specific subgroup. This ignores relevant information from the complementary subgroup. Bayesian dynamic borrowing uses an i...

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Detalles Bibliográficos
Autores principales: Best, Nicky, Price, Robert G., Pouliquen, Isabelle J., Keene, Oliver N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247867/
https://www.ncbi.nlm.nih.gov/pubmed/33475231
http://dx.doi.org/10.1002/pst.2093