Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2

Metamizole is an analgesic and antipyretic drug used intensively in certain countries. Previous studies have shown that metamizole induces cytochrome (CYP) 2B6 and possibly CYP3A4. So far, it is unknown whether metamizole induces additional CYPs and by which mechanism. Therefore, we assessed the act...

Descripción completa

Detalles Bibliográficos
Autores principales: Bachmann, Fabio, Duthaler, Urs, Meyer zu Schwabedissen, Henriette E., Puchkov, Maxim, Huwyler, Jörg, Haschke, Manuel, Krähenbühl, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247900/
https://www.ncbi.nlm.nih.gov/pubmed/33336382
http://dx.doi.org/10.1002/cpt.2141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247900/
https://www.ncbi.nlm.nih.gov/pubmed/33336382
http://dx.doi.org/10.1002/cpt.2141

Ejemplares similares