Synthesis and Initial Characterization of a Selective, Pseudo‐irreversible Inhibitor of Human Butyrylcholinesterase as PET Tracer

The enzyme butyrylcholinesterase (BChE) represents a promising target for imaging probes to potentially enable early diagnosis of neurodegenerative diseases like Alzheimer's disease (AD) and to monitor disease progression in some forms of cancer. In this study, we present the design, facile syn...

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Detalles Bibliográficos
Autores principales: Gentzsch, Christian, Hoffmann, Matthias, Ohshima, Yasuhiro, Nose, Naoko, Chen, Xinyu, Higuchi, Takahiro, Decker, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247983/
https://www.ncbi.nlm.nih.gov/pubmed/33645891
http://dx.doi.org/10.1002/cmdc.202000942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247983/
https://www.ncbi.nlm.nih.gov/pubmed/33645891
http://dx.doi.org/10.1002/cmdc.202000942

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