Metabolic sensor O‐GlcNAcylation regulates megakaryopoiesis and thrombopoiesis through c‐Myc stabilization and integrin perturbation

Metabolic state of hematopoietic stem cells (HSCs) is an important regulator of self‐renewal and lineage‐specific differentiation. Posttranslational modification of proteins via O‐GlcNAcylation is an ideal metabolic sensor, but how it contributes to megakaryopoiesis and thrombopoiesis remains unknow...

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Detalles Bibliográficos
Autores principales: Luanpitpong, Sudjit, Poohadsuan, Jirarat, Klaihmon, Phatchanat, Kang, Xing, Tangkiettrakul, Kantpitchar, Issaragrisil, Surapol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Tissue‐specific Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248081/
https://www.ncbi.nlm.nih.gov/pubmed/33544938
http://dx.doi.org/10.1002/stem.3349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248081/
https://www.ncbi.nlm.nih.gov/pubmed/33544938
http://dx.doi.org/10.1002/stem.3349

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