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Application of metabolic modeling for targeted optimization of high seeding density processes

Process intensification by application of perfusion mode in pre‐stage bioreactors and subsequent inoculation of cell cultures at high seeding densities (HSD) has the potential to meet the increasing requirements of future manufacturing demands. However, process development is currently restrained by...

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Detalles Bibliográficos
Autores principales: Brunner, Matthias, Kolb, Klara, Keitel, Alena, Stiefel, Fabian, Wucherpfennig, Thomas, Bechmann, Jan, Unsoeld, Andreas, Schaub, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248150/
https://www.ncbi.nlm.nih.gov/pubmed/33491766
http://dx.doi.org/10.1002/bit.27693