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Application of metabolic modeling for targeted optimization of high seeding density processes
Process intensification by application of perfusion mode in pre‐stage bioreactors and subsequent inoculation of cell cultures at high seeding densities (HSD) has the potential to meet the increasing requirements of future manufacturing demands. However, process development is currently restrained by...
Autores principales: | Brunner, Matthias, Kolb, Klara, Keitel, Alena, Stiefel, Fabian, Wucherpfennig, Thomas, Bechmann, Jan, Unsoeld, Andreas, Schaub, Jochen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248150/ https://www.ncbi.nlm.nih.gov/pubmed/33491766 http://dx.doi.org/10.1002/bit.27693 |
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