Mechanistic Investigations of Metallo‐β‐lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition

Metallo‐β‐lactamases (MBLs) are zinc‐dependent bacterial enzymes that inactivate essentially all classes of β‐lactam antibiotics including last‐resort carbapenems. At present there are no clinically approved MBL inhibitors, and in order to develop such agents it is essential to understand their inhi...

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Detalles Bibliográficos
Autores principales: Wade, Nicola, Tehrani, Kamaleddin H. M. E., Brüchle, Nora C., van Haren, Matthijs J., Mashayekhi, Vida, Martin, Nathaniel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248298/
https://www.ncbi.nlm.nih.gov/pubmed/33534956
http://dx.doi.org/10.1002/cmdc.202100042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248298/
https://www.ncbi.nlm.nih.gov/pubmed/33534956
http://dx.doi.org/10.1002/cmdc.202100042

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