IRE1-mTOR-PERK Axis Coordinates Autophagy and ER Stress-Apoptosis Induced by P2X7-Mediated Ca(2+) Influx in Osteoarthritis

Moderate-intensity exercise can help delay the development of osteoarthritis (OA). Previous studies have shown that the purinergic receptor P2X ligand gated ion channel 7 (P2X7) is involved in OA development and progression. To investigate the effect of exercise on P2X7 activation and downstream sig...

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Detalles Bibliográficos
Autores principales: Li, Zihao, Huang, Ziyu, Zhang, He, Lu, Jinghan, Wei, Yingliang, Yang, Yue, Bai, Lunhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248364/
https://www.ncbi.nlm.nih.gov/pubmed/34222263
http://dx.doi.org/10.3389/fcell.2021.695041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248364/
https://www.ncbi.nlm.nih.gov/pubmed/34222263
http://dx.doi.org/10.3389/fcell.2021.695041

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