Use of 5‐Thio‐L‐Fucose to modulate binding affinity of therapeutic proteins

The reduction of antibody core‐fucosylation is known to enhance antibody‐dependent cellular cytotoxicity (ADCC). In this study, 5‐Thio‐l‐Fucose (ThioFuc) was investigated as a media and feed supplement for modulating the fucosylation profile of therapeutic proteins and, thereby, improving the result...

Descripción completa

Detalles Bibliográficos
Autores principales: Zimmermann, Martina, Nguyen, Melanie, Schultheiss, Christian M., Kolmar, Harald, Zimmer, Aline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248388/
https://www.ncbi.nlm.nih.gov/pubmed/33501689
http://dx.doi.org/10.1002/bit.27695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248388/
https://www.ncbi.nlm.nih.gov/pubmed/33501689
http://dx.doi.org/10.1002/bit.27695

Ejemplares similares