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High preharvest donor Foxp3 mRNA level predicts late relapse of acute lymphoblastic leukaemia after haematopoietic stem cell transplantation

OBJECTIVES: The curative effect of allogeneic haematopoietic stem cell transplantation (HSCT) for acute leukaemia is due in part to the donor T cell–mediated graft‐versus‐leukaemia immune reaction (GvL). Several studies have suggested that donor CD25+CD4+Foxp3+regulator T cells (Tregs) may decrease...

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Detalles Bibliográficos
Autores principales: Jacobsen, Niels, Frisch, Tina, Keiding, Niels, Heilmann, Carsten, Sengeløv, Henrik, Madsen, Hans O., Marquart, Hanne, Dickmeiss, Ebbe, Andersen, Mette K., Christiansen, Claus B., Ryder, Lars P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248440/
https://www.ncbi.nlm.nih.gov/pubmed/33527553
http://dx.doi.org/10.1111/ejh.13591