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Bivalent chromatin as a therapeutic target in cancer: An in silico predictive approach for combining epigenetic drugs
Tumour cell heterogeneity is a major barrier for efficient design of targeted anti-cancer therapies. A diverse distribution of phenotypically distinct tumour-cell subpopulations prior to drug treatment predisposes to non-uniform responses, leading to the elimination of sensitive cancer cells whilst...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248646/ https://www.ncbi.nlm.nih.gov/pubmed/34153035 http://dx.doi.org/10.1371/journal.pcbi.1008408 |