Broad Influence of Mutant Ataxin-3 on the Proteome of the Adult Brain, Young Neurons, and Axons Reveals Central Molecular Processes and Biomarkers in SCA3/MJD Using Knock-In Mouse Model

Spinocerebellar ataxia type 3 (SCA3/MJD) is caused by CAG expansion mutation resulting in a long polyQ domain in mutant ataxin-3. The mutant protein is a special type of protease, deubiquitinase, which may indicate its prominent impact on the regulation of cellular proteins levels and activity. Yet,...

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Detalles Bibliográficos
Autores principales: Wiatr, Kalina, Marczak, Łukasz, Pérot, Jean-Baptiste, Brouillet, Emmanuel, Flament, Julien, Figiel, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248683/
https://www.ncbi.nlm.nih.gov/pubmed/34220448
http://dx.doi.org/10.3389/fnmol.2021.658339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248683/
https://www.ncbi.nlm.nih.gov/pubmed/34220448
http://dx.doi.org/10.3389/fnmol.2021.658339

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