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Crystal structures of HER3 extracellular domain 4 in complex with the designed ankyrin-repeat protein D5

The members of the human epidermal growth factor receptor (HER) family are among the most intensely studied oncological targets. HER3 (ErbB3), which had long been neglected, has emerged as a key oncogene, regulating the activity of other receptors and being involved in progression and tumor escape i...

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Detalles Bibliográficos
Autores principales: Radom, Filip, Vonrhein, Clemens, Mittl, Peer R. E., Plückthun, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248824/
https://www.ncbi.nlm.nih.gov/pubmed/34196609
http://dx.doi.org/10.1107/S2053230X21006002