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Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome

Chromatin remodeler ALC1 (amplification in liver cancer 1) is crucial for repairing damaged DNA. It is autoinhibited and activated by nucleosomal epitopes. However, the mechanisms by which ALC1 is regulated remain unclear. Here we report the crystal structure of human ALC1 and the cryoEM structure b...

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Detalles Bibliográficos
Autores principales: Wang, Li, Chen, Kangjing, Chen, Zhucheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249414/
https://www.ncbi.nlm.nih.gov/pubmed/34210977
http://dx.doi.org/10.1038/s41467-021-24320-4