The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells

SARS-CoV-2 attacks various organs, most destructively the lung, and cellular entry requires two host cell surface proteins: ACE2 and TMPRSS2. Downregulation of one or both of these is thus a potential therapeutic approach for COVID-19. TMPRSS2 is a known target of the androgen receptor, a ligand-act...

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Detalles Bibliográficos
Autores principales: Leach, D. A., Mohr, A., Giotis, E. S., Cil, E., Isac, A. M., Yates, L. L., Barclay, W. S., Zwacka, R. M., Bevan, C. L., Brooke, G. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249423/
https://www.ncbi.nlm.nih.gov/pubmed/34210968
http://dx.doi.org/10.1038/s41467-021-24342-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249423/
https://www.ncbi.nlm.nih.gov/pubmed/34210968
http://dx.doi.org/10.1038/s41467-021-24342-y

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