Microbial short-chain fatty acids modulate CD8(+) T cell responses and improve adoptive immunotherapy for cancer

Emerging data demonstrate that the activity of immune cells can be modulated by microbial molecules. Here, we show that the short-chain fatty acids (SCFAs) pentanoate and butyrate enhance the anti-tumor activity of cytotoxic T lymphocytes (CTLs) and chimeric antigen receptor (CAR) T cells through me...

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Detalles Bibliográficos
Autores principales: Luu, Maik, Riester, Zeno, Baldrich, Adrian, Reichardt, Nicole, Yuille, Samantha, Busetti, Alessandro, Klein, Matthias, Wempe, Anne, Leister, Hanna, Raifer, Hartmann, Picard, Felix, Muhammad, Khalid, Ohl, Kim, Romero, Rossana, Fischer, Florence, Bauer, Christian A., Huber, Magdalena, Gress, Thomas M., Lauth, Matthias, Danhof, Sophia, Bopp, Tobias, Nerreter, Thomas, Mulder, Imke E., Steinhoff, Ulrich, Hudecek, Michael, Visekruna, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249424/
https://www.ncbi.nlm.nih.gov/pubmed/34210970
http://dx.doi.org/10.1038/s41467-021-24331-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249424/
https://www.ncbi.nlm.nih.gov/pubmed/34210970
http://dx.doi.org/10.1038/s41467-021-24331-1

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