Cargando…

Microbial short-chain fatty acids modulate CD8(+) T cell responses and improve adoptive immunotherapy for cancer

Emerging data demonstrate that the activity of immune cells can be modulated by microbial molecules. Here, we show that the short-chain fatty acids (SCFAs) pentanoate and butyrate enhance the anti-tumor activity of cytotoxic T lymphocytes (CTLs) and chimeric antigen receptor (CAR) T cells through me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luu, Maik, Riester, Zeno, Baldrich, Adrian, Reichardt, Nicole, Yuille, Samantha, Busetti, Alessandro, Klein, Matthias, Wempe, Anne, Leister, Hanna, Raifer, Hartmann, Picard, Felix, Muhammad, Khalid, Ohl, Kim, Romero, Rossana, Fischer, Florence, Bauer, Christian A., Huber, Magdalena, Gress, Thomas M., Lauth, Matthias, Danhof, Sophia, Bopp, Tobias, Nerreter, Thomas, Mulder, Imke E., Steinhoff, Ulrich, Hudecek, Michael, Visekruna, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249424/ https://www.ncbi.nlm.nih.gov/pubmed/34210970 http://dx.doi.org/10.1038/s41467-021-24331-1

Ejemplares similares

The Impact of Gut Microbiota-Derived Metabolites on the Tumor Immune Microenvironment
por: Luu, Maik, et al.
Publicado: (2023)

Functional heterogeneity of gut-resident regulatory T cells
por: Luu, Maik, et al.
Publicado: (2017)

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes
por: Luu, Maik, et al.
Publicado: (2019)

Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T
por: Nerreter, Thomas, et al.
Publicado: (2019)

Selected commensals educate the intestinal vascular and immune system for immunocompetence
por: Romero, Rossana, et al.
Publicado: (2022)

The Role of Short-Chain Fatty Acids and Bile Acids in Intestinal and Liver Function, Inflammation, and Carcinogenesis
por: Visekruna, Alexander, et al.
Publicado: (2021)

Targeting metabolic rewiring might decrease spread of tumor cells: Mitochondrial tRNA modifications promote cancer metastasis
por: Luu, Maik, et al.
Publicado: (2022)

Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid
por: Yuille, Samantha, et al.
Publicado: (2018)

Learning from the microbes: exploiting the microbiome to enforce T cell immunotherapy
por: Staudt, Sarah, et al.
Publicado: (2023)

Exploring the Molecular Mechanisms Underlying the Protective Effects of Microbial SCFAs on Intestinal Tolerance and Food Allergy
por: Luu, Maik, et al.
Publicado: (2020)

CAR-T-Zell-basierte Immuntherapien in der Hämatoonkologie: Fokus auf den Einsatz in der klinischen Routine
por: Steinhardt, M. J., et al.
Publicado: (2023)

Regulation of the effector function of CD8(+) T cells by gut microbiota-derived metabolite butyrate
por: Luu, Maik, et al.
Publicado: (2018)

Tumor-suppressive disruption of cancer subtype-associated super enhancer circuits by small molecule treatment
por: Koeniger, Anke, et al.
Publicado: (2023)

The Role of Immunoproteasomes in Tumor-Immune Cell Interactions in Melanoma and Colon Cancer
por: Leister, Hanna, et al.
Publicado: (2022)

Transcription factor c-Rel is indispensable for generation of thymic but not of peripheral Foxp3(+) regulatory T cells
por: Luu, Maik, et al.
Publicado: (2017)

Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab
por: García-Guerrero, Estefanía, et al.
Publicado: (2020)

Publisher Correction: Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab
por: García-Guerrero, Estefanía, et al.
Publicado: (2021)

P836: ANTIBODY-DRUG CONJUGATES AS POTENTIAL CAR-T CELL SPECIFIC OFF-SWITCH IN MULTIPLE MYELOMA
por: Bielowski, Anna, et al.
Publicado: (2023)

IL-17 and TNF-α Are Key Mediators of Moraxella catarrhalis Triggered Exacerbation of Allergic Airway Inflammation
por: Alnahas, Safa, et al.
Publicado: (2017)

IL-17A-producing CD8(+) T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts
por: Picard, Felix Simon Ruben, et al.
Publicado: (2023)

Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7
por: Vachharajani, Niyati, et al.
Publicado: (2017)

The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4(+) T Cells
por: Kespohl, Meike, et al.
Publicado: (2017)

A Key Role for NF-κB Transcription Factor c-Rel in T-Lymphocyte-Differentiation and Effector Functions
por: Visekruna, Alexander, et al.
Publicado: (2012)

Dietary cellulose induces anti-inflammatory immunity and transcriptional programs via maturation of the intestinal microbiota
por: Fischer, Florence, et al.
Publicado: (2020)

Toxicities of Chimeric Antigen Receptor T Cell Therapy in Multiple Myeloma: An Overview of Experience From Clinical Trials, Pathophysiology, and Management Strategies
por: Zhou, Xiang, et al.
Publicado: (2020)

Current Limitations and Perspectives of Chimeric Antigen Receptor-T-Cells in Acute Myeloid Leukemia
por: Maucher, Marius, et al.
Publicado: (2021)

Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control
por: Singh, Rajeev, et al.
Publicado: (2017)

β5i Subunit Deficiency of the Immunoproteasome Leads to Reduced Th2 Response in OVA Induced Acute Asthma
por: Volkov, Anton, et al.
Publicado: (2013)

The Immune Microenvironment in Pancreatic Cancer
por: Huber, Magdalena, et al.
Publicado: (2020)

CAR T-Cells in Multiple Myeloma: State of the Art and Future Directions
por: Rodríguez-Lobato, Luis Gerardo, et al.
Publicado: (2020)

rKLO8, a Novel Leishmania donovani – Derived Recombinant Immunodominant Protein for Sensitive Detection of Visceral Leishmaniasis in Sudan
por: Abass, Elfadil, et al.
Publicado: (2013)

Quorum Sensing in Halorubrum saccharovorum Facilitates Cross-Domain Signaling between Archaea and Bacteria
por: Thompson, Thomas P., et al.
Publicado: (2023)

DYRK1B blocks canonical and promotes non-canonical Hedgehog signaling through activation of the mTOR/AKT pathway
por: Singh, Rajeev, et al.
Publicado: (2016)

Editorial: Hedgehog signaling pathway in development and cancer
por: Cheng, Steven Y., et al.
Publicado: (2022)

Low dose DTIC is effective and safe in pretreated patients with well differentiated neuroendocrine tumors
por: Mueller, Daniela, et al.
Publicado: (2016)

The Proteasome System in Infection: Impact of β5 and LMP7 on Composition, Maturation and Quantity of Active Proteasome Complexes
por: Joeris, Thorsten, et al.
Publicado: (2012)

CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma
por: Prommersberger, Sabrina, et al.
Publicado: (2021)

Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1
por: Bothur, Evita, et al.
Publicado: (2015)

Measuring Gratitude in Germany: Validation Study of the German Version of the Gratitude Questionnaire-Six Item Form (GQ-6-G) and the Multi-Component Gratitude Measure (MCGM-G)
por: Hudecek, Matthias F. C., et al.
Publicado: (2020)

Expression of catalytic proteasome subunits in the gut of patients with Crohn’s disease
por: Visekruna, Alexander, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_pldnpgvr62tk6i9ivjs25bhaep