Canagliflozin protects against sepsis capillary leak syndrome by activating endothelial α1AMPK

Sepsis capillary leak syndrome (SCLS) is an independent prognostic factor for poor sepsis outcome. We previously demonstrated that α1AMP-activated protein kinase (α1AMPK) prevents sepsis-induced vascular hyperpermeability by mechanisms involving VE-cadherin (VE-Cad) stabilization and activation of p...

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Detalles Bibliográficos
Autores principales: Angé, Marine, De Poortere, Julien, Ginion, Audrey, Battault, Sylvain, Dechamps, Mélanie, Muccioli, Giulio G., Roumain, Martin, Morelle, Johann, Druart, Sébastien, Mathivet, Thomas, Bertrand, Luc, Castanares-Zapatero, Diego, Horman, Sandrine, Beauloye, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249425/
https://www.ncbi.nlm.nih.gov/pubmed/34211080
http://dx.doi.org/10.1038/s41598-021-93156-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249425/
https://www.ncbi.nlm.nih.gov/pubmed/34211080
http://dx.doi.org/10.1038/s41598-021-93156-1

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