Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex

PIWI proteins use guide piRNAs to repress selfish genomic elements, protecting the genomic integrity of gametes and ensuring the fertility of animal species. Efficient transposon repression depends on amplification of piRNA guides in the ping-pong cycle, which in Drosophila entails tight cooperation...

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Detalles Bibliográficos
Autores principales: Huang, Xiawei, Hu, Hongmiao, Webster, Alexandre, Zou, Fan, Du, Jiamu, Patel, Dinshaw J., Sachidanandam, Ravi, Toth, Katalin Fejes, Aravin, Alexei A., Li, Sisi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249470/
https://www.ncbi.nlm.nih.gov/pubmed/34210982
http://dx.doi.org/10.1038/s41467-021-24351-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249470/
https://www.ncbi.nlm.nih.gov/pubmed/34210982
http://dx.doi.org/10.1038/s41467-021-24351-x

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