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Cyclooxygenase inhibition attenuates brain angiogenesis and independently decreases mouse survival under hypoxia

Although cyclooxygenase (COX) role in cancer angiogenesis has been studied, little is known about its role in brain angioplasticity. In the present study, we chronically infused mice with ketorolac, a non‐specific COX inhibitor that does not cross the blood–brain barrier (BBB), under normoxia or 50%...

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Detalles Bibliográficos
Autores principales: Seeger, Drew R., Golovko, Svetlana A., Grove, Bryon D., Golovko, Mikhail Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249483/
https://www.ncbi.nlm.nih.gov/pubmed/33389746
http://dx.doi.org/10.1111/jnc.15291