Cargando…

Angle change of the A-domain in a single SERCA1a molecule detected by defocused orientation imaging

The sarcoendoplasmic reticulum Ca(2+)-ATPase (SERCA) transports Ca(2+) ions across the membrane coupled with ATP hydrolysis. Crystal structures of ligand-stabilized molecules indicate that the movement of actuator (A) domain plays a crucial role in Ca(2+) translocation. However, the actual structura...

Descripción completa

Detalles Bibliográficos
Autores principales: Katoh, Takanobu A., Daiho, Takashi, Yamasaki, Kazuo, Danko, Stefania, Fujimura, Shoko, Suzuki, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249593/
https://www.ncbi.nlm.nih.gov/pubmed/34211016
http://dx.doi.org/10.1038/s41598-021-92986-3