Identification of germline cancer predisposition variants during clinical ctDNA testing

Next-generation sequencing of circulating tumor DNA (ctDNA) is a non-invasive method to guide therapy selection for cancer patients. ctDNA variant allele frequency (VAF) is commonly reported and may aid in discerning whether a variant is germline or somatic. We report on the fidelity of VAF in ctDNA...

Descripción completa

Detalles Bibliográficos
Autores principales: Stout, Leigh Anne, Kassem, Nawal, Hunter, Cynthia, Philips, Santosh, Radovich, Milan, Schneider, Bryan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249601/
https://www.ncbi.nlm.nih.gov/pubmed/34211039
http://dx.doi.org/10.1038/s41598-021-93084-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249601/
https://www.ncbi.nlm.nih.gov/pubmed/34211039
http://dx.doi.org/10.1038/s41598-021-93084-0

Ejemplares similares