A novel strategy for site selective spin-labeling to investigate bioactive entities by DNP and EPR spectroscopy

A novel specific spin-labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the venom of certain rattlesnakes. By specifically labeling the disulfide bridge this molecule becomes accessible for analytical techni...

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Detalles Bibliográficos
Autores principales: Herr, Kevin, Fleckenstein, Max, Brodrecht, Martin, Höfler, Mark V., Heise, Henrike, Aussenac, Fabien, Gutmann, Torsten, Reggelin, Michael, Buntkowsky, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249612/
https://www.ncbi.nlm.nih.gov/pubmed/34211027
http://dx.doi.org/10.1038/s41598-021-92975-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249612/
https://www.ncbi.nlm.nih.gov/pubmed/34211027
http://dx.doi.org/10.1038/s41598-021-92975-6

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