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A novel strategy for site selective spin-labeling to investigate bioactive entities by DNP and EPR spectroscopy
A novel specific spin-labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the venom of certain rattlesnakes. By specifically labeling the disulfide bridge this molecule becomes accessible for analytical techni...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249612/ https://www.ncbi.nlm.nih.gov/pubmed/34211027 http://dx.doi.org/10.1038/s41598-021-92975-6 |