Long-term depletion of cereblon induces mitochondrial dysfunction in cancer cells

Cereblon (CRBN) is a multi-functional protein that acts as a sub-strate receptor of the E3 ligase complex and a molecular chaperone. While CRBN is proposed to function in mitochondria, its specific roles are yet to be established. Here, we showed that knockdown of CRBN triggers oxidative stress and...

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Detalles Bibliográficos
Autores principales: Park, Seulki, Kim, Kidae, Haam, Keeok, Ban, Hyun Seung, Kim, Jung-Ae, Park, Byoung Chul, Park, Sung Goo, Kim, Sunhong, Kim, Jeong-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249880/
https://www.ncbi.nlm.nih.gov/pubmed/33408001
http://dx.doi.org/10.5483/BMBRep.2021.54.6.218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249880/
https://www.ncbi.nlm.nih.gov/pubmed/33408001
http://dx.doi.org/10.5483/BMBRep.2021.54.6.218

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