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Enrichment of CCR6(+)CD8(+) T cells and CCL20 in the lungs of mechanically ventilated patients with COVID‐19
Despite high levels of CXCR3 ligands in mechanically ventilated COVID‐19 patients, BALF CD8 T cells were not enriched in CXCR3(+) cells but rather CCR6(+), likely due to high CCL20 levels in BALF, and had very high PD‐1 expression. In mechanically ventilated, but not ward, patients Th‐1 immunity is...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250259/ https://www.ncbi.nlm.nih.gov/pubmed/33768543 http://dx.doi.org/10.1002/eji.202049046 |
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| author | Saris, Anno Reijnders, Tom D.Y. Reijm, Martine Hollander, Jolien C. de Buck, Kim Schuurman, Alex R. Duitman, JanWillem Heunks, Leo Aman, Jurjan Bogaard, Harm Jan Nossent, Esther J. van der Poll, Tom Bontkes, Hetty J. |
| author_facet | Saris, Anno Reijnders, Tom D.Y. Reijm, Martine Hollander, Jolien C. de Buck, Kim Schuurman, Alex R. Duitman, JanWillem Heunks, Leo Aman, Jurjan Bogaard, Harm Jan Nossent, Esther J. van der Poll, Tom Bontkes, Hetty J. |
| author_sort | Saris, Anno |
| collection | PubMed |
| description | Despite high levels of CXCR3 ligands in mechanically ventilated COVID‐19 patients, BALF CD8 T cells were not enriched in CXCR3(+) cells but rather CCR6(+), likely due to high CCL20 levels in BALF, and had very high PD‐1 expression. In mechanically ventilated, but not ward, patients Th‐1 immunity is impaired. [Image: see text] |
| format | Online Article Text |
| id | pubmed-8250259 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-82502592021-07-02 Enrichment of CCR6(+)CD8(+) T cells and CCL20 in the lungs of mechanically ventilated patients with COVID‐19 Saris, Anno Reijnders, Tom D.Y. Reijm, Martine Hollander, Jolien C. de Buck, Kim Schuurman, Alex R. Duitman, JanWillem Heunks, Leo Aman, Jurjan Bogaard, Harm Jan Nossent, Esther J. van der Poll, Tom Bontkes, Hetty J. Eur J Immunol Letters to the Editor Despite high levels of CXCR3 ligands in mechanically ventilated COVID‐19 patients, BALF CD8 T cells were not enriched in CXCR3(+) cells but rather CCR6(+), likely due to high CCL20 levels in BALF, and had very high PD‐1 expression. In mechanically ventilated, but not ward, patients Th‐1 immunity is impaired. [Image: see text] John Wiley and Sons Inc. 2021-05-11 2021-06 /pmc/articles/PMC8250259/ /pubmed/33768543 http://dx.doi.org/10.1002/eji.202049046 Text en © 2021 The Authors. European Journal of Immunology published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| spellingShingle | Letters to the Editor Saris, Anno Reijnders, Tom D.Y. Reijm, Martine Hollander, Jolien C. de Buck, Kim Schuurman, Alex R. Duitman, JanWillem Heunks, Leo Aman, Jurjan Bogaard, Harm Jan Nossent, Esther J. van der Poll, Tom Bontkes, Hetty J. Enrichment of CCR6(+)CD8(+) T cells and CCL20 in the lungs of mechanically ventilated patients with COVID‐19 |
| title | Enrichment of CCR6(+)CD8(+) T cells and CCL20 in the lungs of mechanically ventilated patients with COVID‐19 |
| title_full | Enrichment of CCR6(+)CD8(+) T cells and CCL20 in the lungs of mechanically ventilated patients with COVID‐19 |
| title_fullStr | Enrichment of CCR6(+)CD8(+) T cells and CCL20 in the lungs of mechanically ventilated patients with COVID‐19 |
| title_full_unstemmed | Enrichment of CCR6(+)CD8(+) T cells and CCL20 in the lungs of mechanically ventilated patients with COVID‐19 |
| title_short | Enrichment of CCR6(+)CD8(+) T cells and CCL20 in the lungs of mechanically ventilated patients with COVID‐19 |
| title_sort | enrichment of ccr6(+)cd8(+) t cells and ccl20 in the lungs of mechanically ventilated patients with covid‐19 |
| topic | Letters to the Editor |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250259/ https://www.ncbi.nlm.nih.gov/pubmed/33768543 http://dx.doi.org/10.1002/eji.202049046 |
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