Polysulfates Block SARS‐CoV‐2 Uptake through Electrostatic Interactions

Here we report that negatively charged polysulfates can bind to the spike protein of SARS‐CoV‐2 via electrostatic interactions. Using a plaque reduction assay, we compare inhibition of SARS‐CoV‐2 by heparin, pentosan sulfate, linear polyglycerol sulfate (LPGS) and hyperbranched polyglycerol sulfate...

Descripción completa

Detalles Bibliográficos
Autores principales: Nie, Chuanxiong, Pouyan, Paria, Lauster, Daniel, Trimpert, Jakob, Kerkhoff, Yannic, Szekeres, Gergo Peter, Wallert, Matthias, Block, Stephan, Sahoo, Anil Kumar, Dernedde, Jens, Pagel, Kevin, Kaufer, Benedikt B., Netz, Roland R., Ballauff, Matthias, Haag, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250366/
https://www.ncbi.nlm.nih.gov/pubmed/33860605
http://dx.doi.org/10.1002/anie.202102717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250366/
https://www.ncbi.nlm.nih.gov/pubmed/33860605
http://dx.doi.org/10.1002/anie.202102717

Ejemplares similares