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Polysulfates Block SARS‐CoV‐2 Uptake through Electrostatic Interactions

Here we report that negatively charged polysulfates can bind to the spike protein of SARS‐CoV‐2 via electrostatic interactions. Using a plaque reduction assay, we compare inhibition of SARS‐CoV‐2 by heparin, pentosan sulfate, linear polyglycerol sulfate (LPGS) and hyperbranched polyglycerol sulfate...

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Detalles Bibliográficos
Autores principales:	Nie, Chuanxiong, Pouyan, Paria, Lauster, Daniel, Trimpert, Jakob, Kerkhoff, Yannic, Szekeres, Gergo Peter, Wallert, Matthias, Block, Stephan, Sahoo, Anil Kumar, Dernedde, Jens, Pagel, Kevin, Kaufer, Benedikt B., Netz, Roland R., Ballauff, Matthias, Haag, Rainer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250366/ https://www.ncbi.nlm.nih.gov/pubmed/33860605 http://dx.doi.org/10.1002/anie.202102717

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