Chemo‐Enzymatic Modification of the 5′ Cap Maintains Translation and Increases Immunogenic Properties of mRNA

Eukaryotic mRNAs are emerging modalities for protein replacement therapy and vaccination. Their 5′ cap is important for mRNA translation and immune response and can be naturally methylated at different positions by S‐adenosyl‐l‐methionine (AdoMet)‐dependent methyltransferases (MTases). We report on...

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Detalles Bibliográficos
Autores principales: van Dülmen, Melissa, Muthmann, Nils, Rentmeister, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250829/
https://www.ncbi.nlm.nih.gov/pubmed/33751748
http://dx.doi.org/10.1002/anie.202100352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250829/
https://www.ncbi.nlm.nih.gov/pubmed/33751748
http://dx.doi.org/10.1002/anie.202100352

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