Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein

STING (stimulator of interferon genes) is a key regulator of innate immunity that has recently been recognized as a promising drug target. STING is activated by cyclic dinucleotides (CDNs) which eventually leads to expression of type I interferons and other cytokines. Factors underlying the affinity...

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Detalles Bibliográficos
Autores principales: Smola, Miroslav, Gutten, Ondrej, Dejmek, Milan, Kožíšek, Milan, Evangelidis, Thomas, Tehrani, Zahra Aliakbar, Novotná, Barbora, Nencka, Radim, Birkuš, Gabriel, Rulíšek, Lubomír, Boura, Evzen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251555/
https://www.ncbi.nlm.nih.gov/pubmed/33616279
http://dx.doi.org/10.1002/anie.202016805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251555/
https://www.ncbi.nlm.nih.gov/pubmed/33616279
http://dx.doi.org/10.1002/anie.202016805

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