Cargando…

Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein

STING (stimulator of interferon genes) is a key regulator of innate immunity that has recently been recognized as a promising drug target. STING is activated by cyclic dinucleotides (CDNs) which eventually leads to expression of type I interferons and other cytokines. Factors underlying the affinity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smola, Miroslav, Gutten, Ondrej, Dejmek, Milan, Kožíšek, Milan, Evangelidis, Thomas, Tehrani, Zahra Aliakbar, Novotná, Barbora, Nencka, Radim, Birkuš, Gabriel, Rulíšek, Lubomír, Boura, Evzen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251555/ https://www.ncbi.nlm.nih.gov/pubmed/33616279 http://dx.doi.org/10.1002/anie.202016805

Ejemplares similares

Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists
por: Vavřina, Zdeněk, et al.
Publicado: (2022)

Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses
por: Konkolova, Eva, et al.
Publicado: (2020)

Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication
por: Dejmek, Milan, et al.
Publicado: (2021)

STING cyclic dinucleotide sensing originated in bacteria
por: Morehouse, Benjamin R., et al.
Publicado: (2020)

STING inhibitors target the cyclic dinucleotide binding pocket
por: Hong, Ze, et al.
Publicado: (2021)

Structural analysis of the putative SARS-CoV-2 primase complex
por: Konkolova, Eva, et al.
Publicado: (2020)

Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin
por: Krafcikova, Petra, et al.
Publicado: (2020)

Endosomolytic Polymersomes Increase the Activity of Cyclic Dinucleotide STING Agonists to Enhance Cancer Immunotherapy
por: Shae, Daniel, et al.
Publicado: (2019)

Polymersome-mediated cytosolic delivery of cyclic dinucleotide STING agonist enhances tumor immunotherapy
por: Zheng, Huan, et al.
Publicado: (2022)

Amplifying STING Activation by Cyclic Dinucleotide-Manganese Particles for Local and Systemic Cancer Metalloimmunotherapy
por: Sun, Xiaoqi, et al.
Publicado: (2021)

The structural model of Zika virus RNA-dependent RNA polymerase in complex with RNA for rational design of novel nucleotide inhibitors
por: Šebera, Jakub, et al.
Publicado: (2018)

High-Throughput Fluorescent Assay for Inhibitor Screening of Proteases from RNA Viruses
por: Cihlova, Bara, et al.
Publicado: (2021)

Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides
por: Yi, Guanghui, et al.
Publicado: (2013)

A STING-based fluorescent polarization assay for monitoring activities of cyclic dinucleotide metabolizing enzymes
por: Karanja, Caroline W., et al.
Publicado: (2020)

Bacterial Cyclic Dinucleotides and the cGAS–cGAMP–STING Pathway: A Role in Periodontitis?
por: Elmanfi, Samira, et al.
Publicado: (2021)

Coronaviral RNA-methyltransferases: function, structure and inhibition
por: Nencka, Radim, et al.
Publicado: (2022)

Structure of STING bound to c-di-GMP Reveals the Mechanism of Cyclic Dinucleotide Recognition by the Immune System
por: Shu, Chang, et al.
Publicado: (2012)

Modified STING-activating cyclic dinucleotide derivatives significantly enhance the anti-tumor activity of therapeutic vaccines
por: Leong, Meredith, et al.
Publicado: (2013)

Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H
por: Walker, Melissa M., et al.
Publicado: (2020)

Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein
por: Dinesh, Dhurvas Chandrasekaran, et al.
Publicado: (2020)

Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio
por: Lu, Zengzeng, et al.
Publicado: (2022)

A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells
por: Pollock, Alex J., et al.
Publicado: (2020)

Enzymatic synthesis of cyclic dinucleotide analogs by a promiscuous cyclic-AMP-GMP synthetase and analysis of cyclic dinucleotide responsive riboswitches
por: Launer-Felty, Katherine D, et al.
Publicado: (2018)

Direct activation of STING in the tumor microenvironment with synthetic cyclic dinucleotide derivatives leads to potent and systemic tumor-specific immunity
por: Corrales, Leticia, et al.
Publicado: (2014)

The Age of Cyclic Dinucleotide Vaccine Adjuvants
por: Gogoi, Himanshu, et al.
Publicado: (2020)

The World of Cyclic Dinucleotides in Bacterial Behavior
por: Aline Dias da, Purificação, et al.
Publicado: (2020)

Supramolecular polymer formation by cyclic dinucleotides and intercalators affects dinucleotide enzymatic processing
por: Nakayama, Shizuka, et al.
Publicado: (2016)

Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase
por: Silhan, Jan, et al.
Publicado: (2023)

Highly Efficient Preparation of Cyclic Dinucleotides via Engineering of Dinucleotide Cyclases in Escherichia coli
por: Lv, Yun, et al.
Publicado: (2019)

Cyclic Dinucleotides in Oral Bacteria and in Oral Biofilms
por: Gürsoy, Ulvi K., et al.
Publicado: (2017)

Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification
por: Sauser, Luca, et al.
Publicado: (2022)

Activation of Gingival Fibroblasts by Bacterial Cyclic Dinucleotides and Lipopolysaccharide
por: Elmanfi, Samira, et al.
Publicado: (2020)

Mass spectrometric characterization of cyclic dinucleotides (CDNs) in vivo
por: Annibal, Andrea, et al.
Publicado: (2021)

Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance
por: Hayoz, Sebastien, et al.
Publicado: (2017)

Quantitation of cyclic dinucleotides by reversed-phase LC-MS/MS
por: Spangler, Christian, et al.
Publicado: (2009)

Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides
por: Elmanfi, Samira, et al.
Publicado: (2018)

SLC19A1 transports immunoreactive cyclic dinucleotides
por: Luteijn, Rutger D., et al.
Publicado: (2019)

The Promise and Challenges of Cyclic Dinucleotides as Molecular Adjuvants for Vaccine Development
por: Yan, Hongbin, et al.
Publicado: (2021)

Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides c(th)GAMP
por: Veth, Simon, et al.
Publicado: (2022)

Biocatalytic Synthesis of Antiviral Nucleosides, Cyclic Dinucleotides, and Oligonucleotide Therapies
por: Van Giesen, Kyle J. D., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_k3ea1fredo61n8jphljsoi2gma