Engineering of a Peptide α‐N‐Methyltransferase to Methylate Non‐Proteinogenic Amino Acids

Introduction of α‐N‐methylated non‐proteinogenic amino acids into peptides can improve their biological activities, membrane permeability and proteolytic stability. This is commonly achieved, in nature and in the lab, by assembling pre‐methylated amino acids. The more appealing route of methylating...

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Detalles Bibliográficos
Autores principales: Song, Haigang, Burton, Antony J., Shirran, Sally L., Fahrig‐Kamarauskaitė, Jūratė, Kaspar, Hannelore, Muir, Tom W., Künzler, Markus, Naismith, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251615/
https://www.ncbi.nlm.nih.gov/pubmed/33856715
http://dx.doi.org/10.1002/anie.202100818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251615/
https://www.ncbi.nlm.nih.gov/pubmed/33856715
http://dx.doi.org/10.1002/anie.202100818

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