Controlled Ligand Exchange Between Ruthenium Organometallic Cofactor Precursors and a Naïve Protein Scaffold Generates Artificial Metalloenzymes Catalysing Transfer Hydrogenation

Many natural metalloenzymes assemble from proteins and biosynthesised complexes, generating potent catalysts by changing metal coordination. Here we adopt the same strategy to generate artificial metalloenzymes (ArMs) using ligand exchange to unmask catalytic activity. By systematically testing Ru(I...

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Detalles Bibliográficos
Autores principales: Biggs, George S., Klein, Oskar James, Maslen, Sarah L., Skehel, J. Mark, Rutherford, Trevor J., Freund, Stefan M. V., Hollfelder, Florian, Boss, Sally R., Barker, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251807/
https://www.ncbi.nlm.nih.gov/pubmed/33616271
http://dx.doi.org/10.1002/anie.202015834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251807/
https://www.ncbi.nlm.nih.gov/pubmed/33616271
http://dx.doi.org/10.1002/anie.202015834

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