Hexa Histidine–Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species

BACKGROUND AND AIMS: Antifibrotic therapy remains an unmet medical need in human chronic liver disease. We report the antifibrotic properties of cytoglobin (CYGB), a respiratory protein expressed in hepatic stellate cells (HSCs), the main cell type involved in liver fibrosis. APPROACH AND RESULTS: C...

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Detalles Bibliográficos
Autores principales: Dat, Ninh Quoc, Thuy, Le Thi Thanh, Hieu, Vu Ngoc, Hai, Hoang, Hoang, Dinh Viet, Thi Thanh Hai, Nguyen, Thuy, Tuong Thi Van, Komiya, Tohru, Rombouts, Krista, Dong, Minh Phuong, Hanh, Ngo Vinh, Hoang, Truong Huu, Sato‐Matsubara, Misako, Daikoku, Atsuko, Kadono, Chiho, Oikawa, Daisuke, Yoshizato, Katsutoshi, Tokunaga, Fuminori, Pinzani, Massimo, Kawada, Norifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251927/
https://www.ncbi.nlm.nih.gov/pubmed/33576020
http://dx.doi.org/10.1002/hep.31752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251927/
https://www.ncbi.nlm.nih.gov/pubmed/33576020
http://dx.doi.org/10.1002/hep.31752

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