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Hexa Histidine–Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species
BACKGROUND AND AIMS: Antifibrotic therapy remains an unmet medical need in human chronic liver disease. We report the antifibrotic properties of cytoglobin (CYGB), a respiratory protein expressed in hepatic stellate cells (HSCs), the main cell type involved in liver fibrosis. APPROACH AND RESULTS: C...
Autores principales: | Dat, Ninh Quoc, Thuy, Le Thi Thanh, Hieu, Vu Ngoc, Hai, Hoang, Hoang, Dinh Viet, Thi Thanh Hai, Nguyen, Thuy, Tuong Thi Van, Komiya, Tohru, Rombouts, Krista, Dong, Minh Phuong, Hanh, Ngo Vinh, Hoang, Truong Huu, Sato‐Matsubara, Misako, Daikoku, Atsuko, Kadono, Chiho, Oikawa, Daisuke, Yoshizato, Katsutoshi, Tokunaga, Fuminori, Pinzani, Massimo, Kawada, Norifumi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251927/ https://www.ncbi.nlm.nih.gov/pubmed/33576020 http://dx.doi.org/10.1002/hep.31752 |
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