Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)

The mammalian membrane‐bound O‐acyltransferase (MBOAT) superfamily is involved in biological processes including growth, development and appetite sensing. MBOATs are attractive drug targets in cancer and obesity; however, information on the binding site and molecular mechanisms underlying small‐mole...

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Detalles Bibliográficos
Autores principales: Lanyon‐Hogg, Thomas, Ritzefeld, Markus, Zhang, Leran, Andrei, Sebastian A., Pogranyi, Balazs, Mondal, Milon, Sefer, Lea, Johnston, Callum D., Coupland, Claire E., Greenfield, Jake L., Newington, Joshua, Fuchter, Matthew J., Magee, Anthony I., Siebold, Christian, Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252026/
https://www.ncbi.nlm.nih.gov/pubmed/33768725
http://dx.doi.org/10.1002/anie.202014457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252026/
https://www.ncbi.nlm.nih.gov/pubmed/33768725
http://dx.doi.org/10.1002/anie.202014457

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