A Box of Chemistry to Inhibit the MEN1 Tumor Suppressor Gene Promoting Leukemia

Targeting protein‐protein interactions (PPIs) with small‐molecule inhibitors has become a hotbed of modern drug development. In this review, we describe a new class of PPI inhibitors that block menin from binding to MLL proteins. Menin is encoded by the MEN1 tumor suppressor, but acts as an essentia...

Descripción completa

Detalles Bibliográficos
Autores principales: Ozyerli‐Goknar, Ezgi, Nizamuddin, Sheikh, Timmers, H. T. Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252030/
https://www.ncbi.nlm.nih.gov/pubmed/33534953
http://dx.doi.org/10.1002/cmdc.202000972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252030/
https://www.ncbi.nlm.nih.gov/pubmed/33534953
http://dx.doi.org/10.1002/cmdc.202000972

Ejemplares similares