Probing activation‐driven changes in coagulation factor IX by mass spectrometry

BACKGROUND: Activated factor IX (FIXa) is an inefficient enzyme that needs activated factor VIII (FVIII) for full activity. Recently, we identified a network of FVIII‐driven changes in FIXa employing hydrogen‐deuterium eXchange mass spectrometry (HDX‐MS). Some changes also occurred in active‐site in...

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Detalles Bibliográficos
Autores principales: Freato, Nadia, van Alphen, Floris P. J., Boon‐Spijker, Mariëtte, van den Biggelaar, Maartje, Meijer, Alexander B., Mertens, Koen, Ebberink, Eduard H. T. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
HAEMOSTASIS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252100/
https://www.ncbi.nlm.nih.gov/pubmed/33687765
http://dx.doi.org/10.1111/jth.15288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252100/
https://www.ncbi.nlm.nih.gov/pubmed/33687765
http://dx.doi.org/10.1111/jth.15288

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