Chronic kidney disease: prevalence and association with handgrip strength in a cross-sectional study
BACKGROUND: Poor physical function is strongly associated with mortality and poor clinical outcomes in adults with chronic kidney disease (CKD). Handgrip strength (HGS) is an important index for physical function in the general population, and the association between HGS and CKD is worth investigati...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252238/ https://www.ncbi.nlm.nih.gov/pubmed/34215205 http://dx.doi.org/10.1186/s12882-021-02452-5 |
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author | Cheng, Yang Liu, Min Liu, Yu Xu, Haifeng Chen, Xiaotian Zheng, Hui Wu, Xiaojun Shen, Zhixiang Shen, Chong |
author_facet | Cheng, Yang Liu, Min Liu, Yu Xu, Haifeng Chen, Xiaotian Zheng, Hui Wu, Xiaojun Shen, Zhixiang Shen, Chong |
author_sort | Cheng, Yang |
collection | PubMed |
description | BACKGROUND: Poor physical function is strongly associated with mortality and poor clinical outcomes in adults with chronic kidney disease (CKD). Handgrip strength (HGS) is an important index for physical function in the general population, and the association between HGS and CKD is worth investigating. METHODS: From September to November 2015, we conducted a cross-sectional study consisting of 10,407 participants in Jurong City, China. Age-related and sex-specific HGS percentile curves were constructed using the GAMLSS method. In addition, logistic regression was applied to estimate the association between HGS and the presence of CKD with odds ratios (ORs) and 95 % confidence intervals (CIs). RESULTS: Participants with low HGS tended to be older and were more likely to have CKD (8.73 %). Smoothed centile curves of HGS showed a similar shape in both sexes: participants peaked at approximately 20–35 years old and gradually decreased after the age of 50. In addition, independent of age and other factors, the decreased presence of CKD was significantly identified in individuals with moderate (OR: 0.64, 95 % CI: 0.49–0.83) and high HGS (OR: 0.37, 95 % CI: 0.23–0.58). CONCLUSIONS: We concluded that HGS was significantly negatively associated with CKD in Chinese community-dwelling persons. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12882-021-02452-5. |
format | Online Article Text |
id | pubmed-8252238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82522382021-07-06 Chronic kidney disease: prevalence and association with handgrip strength in a cross-sectional study Cheng, Yang Liu, Min Liu, Yu Xu, Haifeng Chen, Xiaotian Zheng, Hui Wu, Xiaojun Shen, Zhixiang Shen, Chong BMC Nephrol Research BACKGROUND: Poor physical function is strongly associated with mortality and poor clinical outcomes in adults with chronic kidney disease (CKD). Handgrip strength (HGS) is an important index for physical function in the general population, and the association between HGS and CKD is worth investigating. METHODS: From September to November 2015, we conducted a cross-sectional study consisting of 10,407 participants in Jurong City, China. Age-related and sex-specific HGS percentile curves were constructed using the GAMLSS method. In addition, logistic regression was applied to estimate the association between HGS and the presence of CKD with odds ratios (ORs) and 95 % confidence intervals (CIs). RESULTS: Participants with low HGS tended to be older and were more likely to have CKD (8.73 %). Smoothed centile curves of HGS showed a similar shape in both sexes: participants peaked at approximately 20–35 years old and gradually decreased after the age of 50. In addition, independent of age and other factors, the decreased presence of CKD was significantly identified in individuals with moderate (OR: 0.64, 95 % CI: 0.49–0.83) and high HGS (OR: 0.37, 95 % CI: 0.23–0.58). CONCLUSIONS: We concluded that HGS was significantly negatively associated with CKD in Chinese community-dwelling persons. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12882-021-02452-5. BioMed Central 2021-07-02 /pmc/articles/PMC8252238/ /pubmed/34215205 http://dx.doi.org/10.1186/s12882-021-02452-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Cheng, Yang Liu, Min Liu, Yu Xu, Haifeng Chen, Xiaotian Zheng, Hui Wu, Xiaojun Shen, Zhixiang Shen, Chong Chronic kidney disease: prevalence and association with handgrip strength in a cross-sectional study |
title | Chronic kidney disease: prevalence and association with handgrip strength in a cross-sectional study |
title_full | Chronic kidney disease: prevalence and association with handgrip strength in a cross-sectional study |
title_fullStr | Chronic kidney disease: prevalence and association with handgrip strength in a cross-sectional study |
title_full_unstemmed | Chronic kidney disease: prevalence and association with handgrip strength in a cross-sectional study |
title_short | Chronic kidney disease: prevalence and association with handgrip strength in a cross-sectional study |
title_sort | chronic kidney disease: prevalence and association with handgrip strength in a cross-sectional study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252238/ https://www.ncbi.nlm.nih.gov/pubmed/34215205 http://dx.doi.org/10.1186/s12882-021-02452-5 |
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