Less Unfavorable Salt Bridges on the Enzyme Surface Result in More Organic Cosolvent Resistance

Biocatalysis for the synthesis of fine chemicals is highly attractive but usually requires organic (co‐)solvents (OSs). However, native enzymes often have low activity and resistance in OSs and at elevated temperatures. Herein, we report a smart salt bridge design strategy for simultaneously improvi...

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Detalles Bibliográficos
Autores principales: Cui, Haiyang, Eltoukhy, Lobna, Zhang, Lingling, Markel, Ulrich, Jaeger, Karl‐Erich, Davari, Mehdi D., Schwaneberg, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252522/
https://www.ncbi.nlm.nih.gov/pubmed/33687787
http://dx.doi.org/10.1002/anie.202101642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252522/
https://www.ncbi.nlm.nih.gov/pubmed/33687787
http://dx.doi.org/10.1002/anie.202101642

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