ATR prevents Ca(2+) overload‐induced necrotic cell death through phosphorylation‐mediated inactivation of PARP1 without DNA damage signaling

Hyperactivation of PARP1 is known to be a major cause of necrotic cell death by depleting NAD(+)/ATP pools during Ca(2+) overload which is associated with many ischemic diseases. However, little is known about how PARP1 hyperactivity is regulated during calcium overload. In this study we show that A...

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Detalles Bibliográficos
Autores principales: Li, Zhengke, Wang‐Heaton, Hui, Cartwright, Brian M., Makinwa, Yetunde, Hilton, Benjamin A., Musich, Phillip R., Shkriabai, Nikolozi, Kvaratskhelia, Mamuka, Guan, Shengheng, Chen, Qian, Yu, Xiaochun, Zou, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252533/
https://www.ncbi.nlm.nih.gov/pubmed/33811702
http://dx.doi.org/10.1096/fj.202001636RRR

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252533/
https://www.ncbi.nlm.nih.gov/pubmed/33811702
http://dx.doi.org/10.1096/fj.202001636RRR

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